Discussion on Medication Rules of Cinnamomi Ramulus inShang Han Lun from Dose-Response Relationship
10.3969/j.issn.1005-5304.2017.07.023
- VernacularTitle:从量效关系探讨《伤寒论》桂枝用药规律
- Author:
Wei ZHANG
- Keywords:
Shang Han Lun;
Cinnamomi Ramulus;
dose-response relationship;
single factor logistic regression analysis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2017;24(7):98-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide references for clinical medication through the analysis on the dose-response relationship and compatibility medication rules of Cinnamomi Ramulus.Methods It systematically arranged the provisions containing Cinnamomi Ramulus inShang Han Lun. Relationship between the dose of Cinnamomi Ramulus and the related factors were analyzed by single factor logistic regression analysis and binary correlation analysis by SPSS20.0 statistical software.Results After screening, 40 prescriptions including Cinnamomi Ramulus were selected, accounting for 35.40% in the total prescriptions ofShang Han Lun. The taken dose of every time of Cinnamomi Ramulus had a close relationship with the number of medicine and water consumption, with statistical significance (P=0.000,P=0.004). However, it had no relationship with residual water, water consumption per time and use frequency, without statistical significance (P>0.05). Single factor logistic regression analysis showed whether Cinnamomi Ramulus as a mainmedicine had the close relationship with the taken dose of every time of Cinnamomi Ramulus and use frequency (P=0.008,P=0.043). When Cinnamomi Ramulus and Glycyrrhizae Radix et Rhizoma Praeparata cum Mella were in compatibility, compared with when Cinnamomi Ramulus was not the main medicine, the taken dose of every time of Cinnamomi Ramulus as the main medicine in the group was more frequently used, with statistical significance (P=0.046); however, the number of medicine was statistically lower than when Cinnamomi Ramulus was not main medicine (P=0.043). When Cinnamomi Ramulus and Ephedrae Herba were in compatibility, there was no statistical difference in the taken dose of every time of Cinnamomi Ramulus or the number of medicine (P>0.05). When Cinnamomi Ramulus was the main medicine, it was not in compatibility with Poria or Bupleuri Radix.ConclusionFrom the dose-response relationship, it can be found that the use and compatibility of Cinnamomi Ramulus inShang Han Lun are strict and flexible, and dose law can provide a basis for clinical application.
