Study on the Toxicity of Jianpi Shengxue Granule on Perinatal Rats
10.6039/j.issn.1001-0408.2017.16.08
- VernacularTitle:健脾生血颗粒对围产期大鼠的毒性研究
- Author:
Gang ZHAO
;
Wen QU
;
Fei XIAO
;
Xiaojuan GUO
;
Yanxia YANG
;
Yonghui ZHANG
;
Zhijun HUANG
- Keywords:
Jianpi shengxue granule;
Perinatal rat;
Toxicity;
Offspring rats;
Fertility;
Viability
- From:
China Pharmacy
2017;28(16):2190-2193
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the toxicity effect of Jianpi shengxue granule on perinatal rats. METHODS:Based on body mass,pregnant rats were randomly divided into negative control group and Jianpi shengxue granule low-dose,medium-dose, high-dose groups(0.77,2.31,6.93 g/kg),21 in each group,and intragastrically given relevant medicines from the 15th d of preg-nancy until 21st d after delivery,once a day. Effects of Jianpi shengxue granule on general toxicity and fertility of maternal rats were observed,as well as the effects on athletic ability,learning and memory ability,fertility of F1 offspring and early viability of F2 offspring. RESULTS:In terms of toxicity effect on maternal rats,compared with control group,the days of pregnancy in Jianpi shengxue granule high-dose group was significantly prolonged(P<0.05),initial body mass of administration was significantly re-duced (P<0.01). In terms of toxicity effect on offspring,compared with negative control group,the initial body mass of F1 off-spring in Jianpi shengxue granule high-dose group was significantly reduced(P<0.05),the time of 4th and 5th time for founding underwater platform was significantly shortened(P<0.01),and there was no obvious effect on fertility of F1 offspring and early vi-ability of F2 offspring (P>0.05);there was no obvious effect on the indexes of offspring in Jianpi shengxue granule medium-dose,low-dose groups. CONCLUSIONS:The no toxic dose of Jianpi shengxue granule in maternal and offspring rats is 2.31 g/kg.
