Kinetics of serum HBsAg in chronichepatitis B patients with nucleos(t)ide analogues treatment
- VernacularTitle:经核苷(酸)类药物治疗的慢性乙型肝炎HBsAg定量分析
- Author:
Mengyang ZHANG
;
Susu YE
;
Xiaoqing LIU
;
Shaoxia XU
;
Baotong ZHOU
;
Xiaochun SHI
;
Hong XU
;
Yang HAN
;
Lifan ZHANG
;
Guohua DENG
- Keywords:
chronic hepatitis B;
nucleos(t)ide analogues;
quantitative hepatitis B surface antigen
- From:
Basic & Clinical Medicine
2017;37(6):817-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize and analyze the dynamic change of HBsAg levels in patients with chronic Hepatitis B (CHB) after receiving nucleos(t)ide analogues (NAs) as antiviral treatment.Methods Patients who were performed quantitative Hepatitis B surface antigen(qHBsAg) from July 30, 2012 to December 30,2016 in Peking Union Medical College Hospital were retrospectively enrolled.qHBsAg, HBV DNA, HBeAg were collected and analyzed at baseline and at 192-week follow-up every 24 weeks.qHBsAg and HBeAg were assessed with chemiluminesent microparticle immuno assay(CMIA).HBV DNA was assessed with PCR and COBAS Amplicor.Results 60 patients were included.Patients in HBeAg-positive group had higher HBV DNA than that in HBeAg-negative group (P<0.05)at baseline and the two groups both were under detection limit after 48 weeks.BaselineqHBsAg in HBeAg positive-group and negative-group were (3.43±0.73) log10 IU/mL, (3.08±0.47) log10 IU/mL respectively.qHBsAg in HBeAg-positive group was higher than that in HBeAg negative-group on all follow-ups(P<0.05) except 48weeks.However on 168 weeks and 192 weeks, difference between the two groups was statistically significant(P<0.05).In HBeAg-positive group,quantitative HBeAg dropped significantly during antiviral treatment.Conclusions HBV replication can be suppressed in the process of long-term NAs treatment in CHB patients.However qHBsAg decline is not so obvious, which indicates that HBsAg cleavence is difficult,and long-term NAs therapy is still necessary.
