Progress in neural stem cells therapy for traumatic brain injury
- VernacularTitle:神经干细胞治疗脑创伤的研究进展
- Author:
Xiao ZHANG
;
Junji WEI
;
Renzhi WANG
- Keywords:
traumatic brain injury;
neural stem cells;
transplantation;
neural regeneration;
cytokines
- From:
Basic & Clinical Medicine
2017;37(6):880-883
- CountryChina
- Language:Chinese
-
Abstract:
The neural stem cells (NSCs) can migrate into the injured area and differentiate into neurons or oligodendrocytes.Endogenous neurogenesis may potentially be harnessed as a putative therapy for neural injury.But the complex micro-environment due to TBI will be one of the biggest challenges for endogenous NSCs to perform neural regenerations.Exogenous NSCs have been shown to be able to survive in host tissues and regulate microenvironment via paracrine effects.Thus, transplantation of NSCs to assist neural regeneration has become an attractive option.Recently, rapid advances in the stem cell biology have raised appealing possibilities of replacing damaged or lost neural cells by transplantation of in vitro-expanded stem cells and/or their neuronal progeny.
