Research advances in radiation-induced lung injury and Th1/Th2 imbalance
10.3760/cma.j.issn.1004-4221.2017.06.023
- VernacularTitle:放射性肺损伤与Th1/Th2免疫失衡研究进展
- Author:
Jing CHENG
;
Ye YAO
;
Conghua XIE
- Keywords:
Radiation-induced pneumonia;
Radiation-induced pulmonary fibrosis;
Th1 or Th2 immune reactions;
Cytokines
- From:
Chinese Journal of Radiation Oncology
2017;26(6):706-710
- CountryChina
- Language:Chinese
-
Abstract:
Normal lung tissues are inevitably exposed to X-ray in thoracic radiotherapy,causing radiation-induced lung injury (RILI).The main pathological manifestations include the accumulation of inflammatory cells,release of cytokines,accumulation and proliferation of fibroblasts,and excessive deposition of alveolar interstitial collagen in the irradiated region.RILI severely affects the treatment compliance and quality of life and even threatens the life in the patients receiving radiotherapy.In recent years,numerous studies have found that Th1/Th2 imbalance is closely associated with the development and progression of RILI,and the cytokine network plays an executive role in the progression of RILI.Therefore,restoring the Th1/Th2 balance in vivo may provide a new way to prevent and treat RILI.
