Minimum Cost Analysis of 2 Therapy Plans for Elderly Community Acquired Pneumonia
10.6039/j.issn.1001-0408.2017.23.03
- VernacularTitle:老年社区获得性肺炎两种药物治疗方案的最小成本分析
- Author:
Li ZHANG
;
Yang ZHANG
;
Yunfei WANG
;
Yijun WANG
- Keywords:
Community acquired pneumonia;
Elderly patient;
Moxifloxacin;
Piperacillin/tazobactam;
Azithromycin;
Mini-mum cost analysis;
Pharmacoeconomics
- From:
China Pharmacy
2017;28(23):3180-3182
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare clinical efficacy,ADR and cost of moxifloxacin alone vs. piperacillin/tazobactam com-bined with azithromycin in the treatment of elderly community acquired pneumonia(CAP). METHODS:In retrospective study, 60 elderly CAP patients were selected from respiratory department of a third grade Class A hospital during Oct. 2015-Apr. 2016, and then divided into group A,B with 30 cases in each group according to the medication regimen. Group A was given Moxifloxa-cin hydrochloride and sodium chloride injection 250 mL,ivgtt,qd;group B was given Azithromycin latobionate for injection 0.50 g,ivgtt,qd+Piperacillin sodium and tazobactam sodium for injection 3.375 g,ivgtt,q8 h. Both groups were treated for 10 d. Clini-cal efficacy,bacteriological efficacy and the occurrence of ADR were compared between 2 groups. The economics of 2 therapy plans were evaluated. RESULTS:Total response rates of group A and B were 90.00% and 93.33%;bacterial clearance rates were 85.00% and 86.36%;the incidence of ADR were 3.33% and 6.67%,without statistical significance(P>0.05). Minimum cost analysis was adopted for economic evaluation;treatment cost of group A was 16646.51 yuan,and that of group B was 19605.74 yuan;the cost of group A was lower than group B. The results of minimum cost analysis were supported by sensitivity analysis. CONCLUSIONS:For empiric treatment of antibiotics in elderly CAP patients,moxifloxacin alone should be the first choice. The therapy plan is effective,low-cost and safe.
