Correlation between Galectin-3 and hematologic malignant neoplasms

VernacularTitle:半乳糖凝集素3表达与血液系统恶性肿瘤的相关性
Author: Na GAO
Keywords: Galectin-3; Leukemia; Lymphoma; Myeloma
From: Journal of Leukemia & Lymphoma 2017;26(8):508-512
CountryChina
Language:Chinese
Abstract: Galectin-3, encoded by LGALS3 (14q21-22) and secreted by normal cells and tumor cells, is a member of Galectin family and can be detected both in serum and plasma. Galectin-3 is considered to be an important indicator of the assessment of the patients with malignant tumor and heart failure. The high expression of Galectin-3 may be correlated with poor response to chemotherapy, high recurrence rate, low survival rate and short survival period, which can be a prognostic marker in some solid tumors, including thyroid cancer, gastric cancer, colon cancer, breast cancer. Foreign studies have found that the high expression of Galectin-3 in many kinds of malignant tumors is closely related to the prognosis of the disease. In this paper, the correlation between Galectin-3 and blood tumors is reviewed to study the expression of Galectin-3 in the blood tumors and its relationship with the occurrence, development and prognosis of the tumor, and to explore the theoretical basis for the targeted therapy of Galectin-3.