Progress of statins' effect on endometrial carcinoma
10.3760/cma.j.issn.1006-9801.2017.08.018
- VernacularTitle:他汀类药物对子宫内膜癌作用的研究进展
- Author:
Yong ZHANG
;
Jing KANG
- Keywords:
Endometrial neoplasms;
Statins
- From:
Cancer Research and Clinic
2017;29(8):570-573
- CountryChina
- Language:Chinese
-
Abstract:
Statins are a class of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, which are pervasively used to reduce blood cholesterol concentration in hypercholesterolemic patients and prevent cardiovascular diseases in clinic, duo to excellent drug efficiency and good safety. In recent years, increasing evidences have demonstrated that statins have potential anti-tumor effect through inhibiting cancer cells growth, invasion, metastasis, preventing angiogenesis, promoting cancer cells apoptosis and synergetically enhancing the effect of radiotherapy and chemotherapy. However, there are no domestic reports about statins' effect on endometrial carcinoma, additionally, conclusions of related foreign studies are inconsistent. This review summarized the effect of statins on endometrial carcinoma.
