Clinicopathological analysis of intestinal polypoid lymphoma in children: report of 15 cases
10.3760/cma.j.issn.1009-9921.2017.08.007
- VernacularTitle:儿童肠道息肉样淋巴瘤15例临床病理分析
- Author:
Hui HUANG
;
Wenping YANG
;
Songtao ZENG
;
Hongyan XU
;
Yan WU
;
Qingqiang DENG
;
Feng XIONG
- Keywords:
Child;
Gastrointestinal tract;
Lymphoma;
Pathology;
clinical;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2017;26(8):475-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathologic features of intestinal polypoid lymphoma (PL) in children. Methods The clinicopathologic data of 15 cases of pediatric intestinal PL in Jiangxi Provincial Children 's Hospital were retrospectively analyzed. Immuohistochemistry was used to detect the expressions of CD10, bcl-6, bcl-2, MUMl and ERCC1, then EB virus (EBV)-encoded RNA (EBER) status was tested by using in situ hybridization. Results Amongst 15 cases studied, 13 cases were Burkitt lymphoma (BL), 1 case was diffuse large B-cell lymphoma (DLBCL) and 1 case was between DLBCL and BL (DLBCL/BL). The positive rate of CD10, bcl-6, bcl-2, MUMl, ERCC1 and EBER were 100.0%(13/13), 92.3%(12/13), 0, 7.7 % (1/13), 15.4 % (2/13), 53.8 % (7/13), respectively in 13 BL cases. The clinical stage of 13 patients with BL: 11 cases (84.6 %) Ⅱ stage, 1 case (7.7 %) Ⅲ stage, 1 case (7.7 %) Ⅳstage. The clinical stage of DLBCL and BL/DLBCL: Ⅱstage. 14 cases of PL had survival time without tumors, 24-120 months follow-up, and 1 BL patient inⅣstage without chemotherapy died after 2 months. Conclusion BL is a major subtype of intestinal PL in children, which shows a low clinical stage and a good prognosis.
