Research on Metformin pharmacogenomics in the treatment of type 2 diabetes
10.3969/j.issn.1006-6187.2017.08.018
- VernacularTitle:二甲双胍治疗2型糖尿病的药物基因组学研究进展
- Author:
Simin ZHANG
;
Xueyao HAN
;
Linong JI
- Keywords:
Metformin;
Diabetes mallitus,type 2;
Pharmacogenomics
- From:
Chinese Journal of Diabetes
2017;25(8):760-764
- CountryChina
- Language:Chinese
-
Abstract:
Metformin is a first-line therapy for type 2 diabetes mellitus.Individual variation in response to metformin exists in clinical practice,which is associated with genetic background.Current researches focus on elucidating the relationship between the polymorphisms of genes and the absorption,transportation,metabolism,and excretion of metformin,and also pharmacogenomics of metformin treatment.Pharmacogenomics also provides theoretical basis for individualized therapy.Here,we reviewed the literature progress for metformin pharmacogenomics.
