Value of fecal tumor M2 pyruvate kinase in colorectal adenoma detection
10.3760/cma.j.issn.1008-6315.2017.08.011
- VernacularTitle:粪便肿瘤型M2丙酮酸激酶在大肠腺瘤检测中的价值
- Author:
Yu ZHANG
;
Yuanye JIANG
;
Mingli FENG
;
Jinping WANG
;
Lei JIN
;
Qin CAO
- Keywords:
Fecal tumor M2 pyruvate kinase;
Colorectal adenoma;
Diagnostic test
- From:
Clinical Medicine of China
2017;33(8):714-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the value of fecal tumor M2-PK in the detection of colorectal adenoma and to evaluate its potential as a screening tool for colorectal adenoma.Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the fecal tumor M2-PK in stool samples of 65 patients with colorectal adenoma and 25 controls.At the same time,the peripheral blood tumor markers such as carcinoembryonic antigen (CEA),carbohydrate antigen (CA) 19-9,CA24-2 and fecal occult blood test (FOBT) were detected in the colorectal adenoma group.Results The detection value of fecal tumor M2-PK in the colorectal adenoma group showed a significant increase,compared with the control group((6.033±4.123) U/ml vs.(2.782±1.464) U/ml,t=-3.839,P=0.000).The highest detection value was found in the group where the diameter of adenoma was greater than or equal to 2 cm ((8.775±6.548) U/ml,t=9.635,P=0.034).The larger the diameter of adenoma,the higher the positive rate of fecal tumor M2-PK (85.7% vs.41.7% vs.29.6%,χ2=11.977,P=0.003).In the colorectal adenoma group,The positive detection rate of fecal tumor M2-PK was significantly higher than that of CEA,CA19-9,CA24-2 and FOBT (46.2% vs.6.2% vs.1.5% vs.1.5% vs.27.7%,?2=76.607,P=0.000).Conclusion Fecal tumor M2 pyruvate kinase has a good clinical value in the diagnosis of colorectal adenoma.
