Association analysis between HLA-DRB1 alleles and pemphigus vulgaris in a Han population in Sichuan

VernacularTitle:HLA-DRB1等位基因与四川汉族人寻常型天疱疮的相关性研究
Author: Dengmei XIA ; Wei YAN ; Fei XU ; Lian WANG ; Wei LI
Keywords: Pemphigus; HLA-DRB1 Chains; Allele
From: Chinese Journal of Dermatology 2017;50(8):589-591
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between HLA-DRB1 alleles and pemphigus vulgaris (PV) in a Han population in Sichuan.Methods Polymerase chain reaction with sequencespecific primer (PCR-SSP) method was used for low-resolution and high-resolution typing of HLA-DRB1 alleles in 19 patients of Han nationality with PV and 25 healthy controls in Sichuan.Allele frequencies were calculated,and differences in the allele frequency between the above two groups were compared by using chisquare test.Results Totally,9 kinds of DRB 1 low-resolution alleles and 19 kinds of DRB 1 high-resolution alleles were identified in the PV patients and healthy controls.Frequencies of the DRB1* 14 allele (39.47％[15/38] vs.8.00％[4/50],x2 =17.43,P ＜ 0.05) and DRB1*1405 allele (15.79％[6/38] vs.2.00％[1/50],x2 =4.25,P ＜ 0.05) were significantly higher in the PV patients than in the healthy controls.Conclusion The HLA-DRB1*14 allele may be a common susceptibility gene for PV in the Han population in Sichuan,and the HLA-DRB1* 1405 allele may be most closely associated with PV.