Comparison of Nalmefene and Naloxone on postoperative recovery for neonates by laparoscopic pyloromyotomy
10.3969/j.issn.1007-1989.2017.08.006
- VernacularTitle:应用纳美芬与纳洛酮对新生儿腹腔镜幽门环切术后苏醒的作用研究
- Author:
Zheng HU
;
Jianshe WANG
;
Longde ZHAO
;
Meimin QU
- Keywords:
Nalmefene;
Naloxone;
neonate;
laparoscopic;
anesthesia recovery
- From:
China Journal of Endoscopy
2017;23(8):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Nalmefene on postoperative recovery on neonates by laparoscopic pyloromyotomy. Methods Elective laparoscopic pyloromyotomy for 60 neonates under general anestheisa, aged 15 ~ 28 days, ASA Ⅱ~Ⅲ , were randomly divided into two groups: Nalmefene group (M group) and Naloxone group (L group), 30 cases in each. Nalmefene 0.25 μg/kg and Naloxone 1.00 μg/kg were respectively administrated in M group and L group when the procedures finished. Parameters SpO2, MAP, HR and RR were measured and analyzed statistically at different times: end of surgery before drugs were used (T0), 10 min after administration (T1), 30 mins after extubation (T2) and 2 h after extubation (T3). Meanwhile observing spontaneous breathing recovery time, extubation time, residence time at PACU and adverse events 24 s after surgery. Results There were no actual differences in the value of MAP, HR and SpO2 at T0, T1, T2 and T3 times in the two groups (P > 0.05). However, the values of RR was significant faster at T1, T2 and T3 times than that at T0 in both groups (P < 0.05), compared with L group, the value of RR at T1 was much faster in M group (P < 0.05). The times of extubation and residence at PACU have significant differences in M group than that in L group (P < 0.05). The adverse events in both groups have no differences. Conclusion Nalmefene can facilitate the recovery at laparoscopic pyloromyotomy on neonates. Compared with naloxone, it can reduce the extubation time, and promote the early rehabilitation.
