Necroptosis and tumor
- VernacularTitle:坏死性凋亡与肿瘤
- Author:
Lianzi WANG
;
Tao LI
- Keywords:
necroptosis;
RIPK;
caspase-8;
CHIP;
tumor
- From:
Basic & Clinical Medicine
2017;37(7):1051-1054
- CountryChina
- Language:Chinese
-
Abstract:
Necroptosis,it is activated by the formation of necrosome,is a way of programmed cell death that independent of the activation of caspase.Necroptosis is regulated by many factors,for example,RIPK1 can initiate necroptosis,but also inhibit necroptosis;caspase-8 is the key negative regulation factor of necroptosis;CHIP is a new regulation protein of necroptosis.Triggering necroptosis is a promising strategy to overcome apoptosis resistance in cancer.
