Progressive osseous heteroplasia: three case reports
10.3760/cma.j.issn.0412-4030.2017.08.012
- VernacularTitle:进行性骨发育异常三例分析
- Author:
Xiaoyan ZHANG
;
Tingting WANG
;
Lin WANG
- Keywords:
Bone diseases,developmental;
Skin manifestations;
Pathologic processes;
Diagnosis;
Therapy;
Progressive osseous heteroplasia
- From:
Chinese Journal of Dermatology
2017;50(8):595-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinicopathological features,diagnosis and treatment of progressive osseous heteroplasia (POH).Methods Clinicopathological data were collected from 3 cases of POH,and analyzed retrospectively.Related literature was also reviewed.Results All the 3 patients were female,and developed POH within a few days to months after birth.POH clinically manifested as light pink or skin-colored indurated papules,nodules or plaques scattered over the scalp,trunk and extremities without subjective symptoms.Histopathological examination showed that there were flaky bone or bone-like tissues in the middle and lower dermis.Serum levels of calcium,phosphate and parathyroid hormone were normal in the 3 children.Case 1 was treated with oral sodium bicarbonate tablets and surgical resection of skin lesions on the right lower abdomen.During the follow-up for about 7 months,the skin lesions on the right lower abdomen did not recur,while other skin lesions became more bulging,larger and harder,and new skin lesions occurred.Case 2 was treated with topical adapalene gel,and these skin lesions did not increase in number,but became larger and harder.Case 3 received no treatment,and was lost to follow-up.Conclusion POH clinically manifests as indurated maculopapules and plaques progressively affecting deeper skin tissues,and there are no effective therapies or prevention approaches at present.
