Research progress in contrast-induced nephropathy
10.3969/j.issn.1008-794X.2017.06.023
- VernacularTitle:对比剂肾病研究进展
- Author:
Yuping WANG
;
Shilin SHEN
;
Dongjun SU
;
Yuezhen HE
;
Fuhuan CHEN
- Keywords:
contrast media;
contrast-induced nephropathy;
prevention
- From:Journal of Interventional Radiology
2017;26(6):572-575
- CountryChina
- Language:Chinese
-
Abstract:
With the wide application of contrast media in modem medicine,contrast-induced nephropathy (CIN) has attracted more clinical attention.Renal ischemia and renal tubular toxicity have been considered to be the pathogenesis of CIN.The most promising biomarkers,except for serum creatinine,include neutrophil gelatinase associated lipocalin (NGAL),cystatin C (Cys C),kidney injury molecule-1 (KIM-1),urine N-acetyl beta-D amino glucosidase (NAG) and micro molecular RNA (microRNA).Before use of contrast media for angiography,both the patient's own risk factors and the contrast-associated risk factors should be carefully evaluated.The patient's own risk factors include basic renal function,diabetes,anemia,homocysteine,etc.The contrast-associated risk factors include the osmotic pressure,viscosity,dosage,application frequency of the used contrast agent,etc.At present,hydration therapy is still the main method for CIN,and other therapeutic methods include medication,such as statins,vasodilators,antioxidants,traditional Chinese medicine,etc.,and blood purification therapy.This paper aims to make a brief summary about the research progress in CIN,focusing on its diagnosis,pathogenesis,risk factors and preventive measures.
