Down-regulation of FTO in human gastric cancer and its effect on cell line MGC-803 function
- VernacularTitle:FTO在胃癌组织中的表达降低及其对细胞系MGC-803功能的影响
- Author:
Jingnan PI
;
Jie ZHANG
;
Xuepeng WANG
;
Jiachao XIONG
;
Jia YU
- Keywords:
gastric cancer;
MGC-803;
FTO
- From:
Basic & Clinical Medicine
2017;37(7):907-911
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of FTO in gastric cancer tissues and the functional significance of FTO in MGC-803 cell line.Methods The FTO mRNA was detected by RT-qPCR in 54 cases of gastric cancer samples and their paired adjacent normal control tissues.The effect of FTO overexpression in MGC-803 on cell proliferation,cell migration and invasion were detected by CCK-8,wound heal and ranswell assays,respectively.Results The expression of FTO mRNA was significantly lower than that of adjacent tissues(P＜O.05).Furthermore,overexpression of FTO in MGC-803 cells inhibited cell proliferation,cell migration and invasion.Conclusions FTO is low expressed in gastric cancer tissues and inhibits gastric cancer cell line MGC-803 proliferation,migration and invasion.FTO is closely associated with the development of gastric cancer.
