Arterial infusion of Oxaliplatin for treatment of liver metastases from colorectal cancer after surgery
10.13929/j.1672-8475.201611015
- VernacularTitle:动脉微泵灌注奥沙利铂治疗结直肠癌术后肝转移
- Author:
Hui LI
;
Xu JIANG
;
Chaoai YANG
;
Weixing WANG
;
Wenhui CHEN
;
Jingyu LIU
;
Hang LIU
;
Jijin YANG
- Keywords:
Colorectal neoplasms;
Neoplasm metastasis;
Liver;
Oxaliplatin
- From:
Chinese Journal of Interventional Imaging and Therapy
2017;14(8):455-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effectiveness,safety and influencing factors of arterial infusion of oxaliplatin for the treatment of colorectal l1iver metastases after surgery.Methods Totally 68 colorectal liver metastases after surgery patients pathologically confirmed received at least two course of arterial infusion of oxaliplatin combined with TACE.According to postoperative intravenous chemotherapy,the patients were divided into group A (no chemotherapy) and group B (chemotherapy).Survival time of patients were followed up.According to the efficacy of solid tumor evaluation criteria the objective effect was evaluated,the adverse reactions were compared between two groups.Cox regression analysis was performed to assess the possible factors influencing survival time.Results The median overall survival (OS) of all the 68 patients was 18 months,with complete remission 16 cases,partial remission 26 cases,stable diseasse 21 cases,stable diseasse 5 cases,the response rate (RR) was 61.76％ (42/68).The median progression-free survival (PFS) was 10 months.The RR,OS and PFS had no statistical difference (all P＞0.05).The variables that eventually entered the Cox regression model were tumor differentiation (P=0.003,hazard ratio 2.202).Conclusion Arterial infusion of oxaliplatin and TACE is effective in treating colorectal liver metastases after surgery,with high objective response rate.
