Analysis of influencing factors of adrenal hemorrhage and necrosis in critically ill children
10.3760/cma.j.issn.1008-1372.2017.07.007
- VernacularTitle:重症患儿肾上腺出血坏死的影响因素分析
- Author:
Xueli QUAN
;
Yimin ZHU
;
Xiulan LU
;
Weijian CHEN
;
Jun QIU
- Keywords:
Critical illness;
Adrenal gland diseases/CO;
Hemorrhage/CO;
Necrosis/CO
- From:
Journal of Chinese Physician
2017;19(7):988-991
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the adrenal histopathology damage in critically ill non-survival children,and the incidence of adrenal damage,and to explore the risk factors for the adrenal hemorrhage and necrosis in critically ill children.Methods A total of 141 critically ill non-survival children was admitted in this study in Hunan Children's Hospital from January 1,2005 to December 30,2012.Clinical data in children were systematically collected,including age,sex,sodium,potassium,blood gas analysis,liver and kidney function,blood clotting function,etiology,treatment and pediatric clinical illness score (PCIS) or neonatal critical illness score (NCIS),and pathological data.All data were analyzed by SPSS 18.0.Results Logistic regression analysis showed the factors of adrenal hemorrhage and necrosis of critically ill non-survival children were sepsis,PCIS score ＜ 80 critically ill children are risk factors for adrenal hemorrhage necrosis (P ＜ 0.05),ORwas 3.659 (95％ CI:1.344-9.965),and 2.325 (95％ CI:1.028 -5.258).Intravenous corticosteroids were protective factors for critically ill non-survival children with adrenal hemorrhage necrosis (P ＜ 0.05),and ORwas 0.377 (95％ CI:0.163-0.875).Conclusions There were two significant risk factors of adrenal hemorrhage and necrosis:sepsis and critical illness score less than 80 points.Intravenous corticosteroid is a protective factor in critically ill children.
