Expression and the effect of preoperative radiotherapy of ET-1 and PKM2 in rectal carcinoma

VernacularTitle:ET-1和PKM2在直肠癌组织中的表达与术前放疗效果的关系
Author: Jumei ZHOU ; Rong LIANG ; Suyu ZHU ; Zheng WU ; Zhen XI ; Min ZOU ; Yun LYU ; Shaolin NIE
Keywords: Endothelin-1/ME; Pyruvate kinase/ME; Rectal neoplasms/RT/ME
From: Journal of Chinese Physician 2017;19(7):1010-1013
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship of expression and the effect of preoperative radiotherapy of endothelin-1 (ET-1) and pyruvate kinase M-2 (PKM2) in rectal carcinoma.Methods Immunohistochemical method was used to detect the expression of ET-1 and PKM2 proteins of rectal cancer tissues in 96 cases.The expressions of ET-1 and PKM2 were analyzed with the effect of preoperative radiotherapy in rectal cancer tissue.Results The high expression of ET-1 protein was 59 cases (61.46％).The high expression of PKM2 proteins was 54 cases (56.25％).The high expressions of ET-1 and PKM2 protein were worsen the effect of tumor regressive grade (TRG) than lower expressions of those after preoperative radiotherapy of rectal cancer tissue (P ＜ 0.05).The protein expression of ET-1 and PKM2 were positively correlated (P =0.006).Conclusions The high expressed ET-1 and PKM2 proteins in rectal cancer are closely related to preoperative radiotherapy resistance.ET-1 and PKM2 proteins are expected to become new targets of radiotherapy sensitivity and radiotherapy sensitization of rectal cancer.