Research progress on mechanism of antibody-dependent enhancement

VernacularTitle:抗体依赖增强效应发生机制研究进展
Author: Weizhuang YUAN ; Yicheng YANG ; Xuling LIU ; Xiaoen HE ; Yuan HUI ; Yujing LIU ; Ying LI ; Wei ZHAO
Keywords: antibody-dependent enhancement; mechanism; pathogen
From: Chinese Journal of Zoonoses 2017;33(7):650-657
CountryChina
Language:Chinese
Abstract: In many pathogens infection,especially virus,antibody-dependent enhancement(ADE) can aggravate the infection and lead to severe diseases.In this immunopathological phenomenon,virus-specific antibodies enhance the entry of virus into monocytes,macrophages and granulocytic cells and even the replication of virus through different mechanism.This phenomenon has been reported in numerous pathogens including virus,bacteria and parasite and the mechanisms of ADE vary from different species.Further study of ADE can promote the vaccine research and development to make the most use of vaccine and prevent human body from pathogens,which will be helpful to control the spread of pathogens including Zika virus.In the present review,we review the research progress of ADE mechanism in recent years,including antibodies mediating,receptors mediating,complement mediating,viral proteins mediating and cellular mediating ADE.In addition,dengue virus,human immunodeficiency virus,Coxsackie virus,Ebola virus,Zika virus and other pathogens will be illustrated respectively.This review provides insights on the different mechanism of ADE in different pathogens.