Effects of Acorustatarinowii Schott on chronic restraint stress mice and its mechanisms
10.3969/j.issn.1006-5725.2017.16.011
- VernacularTitle:石菖蒲对慢性应激小鼠记忆的影响及其机制
- Author:
Guangming WANG
;
Shaolin LI
;
Lin CAI
;
Gang LI
- Keywords:
acorustatarinowii Schott;
chronic restraint stress;
memory;
corticosteroid
- From:
The Journal of Practical Medicine
2017;33(16):2650-2652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of Acorustatarinowii Schott(ATS)on chronic restraint stress mice and its possible mechanisms. Methods Chronic stressed mice underwent a repeated 8h/d constraint in a specific behavior blocker ,however ,only CSA mice received once gavages of 4.5 g/(kg · d)ATS decoction for con-secutive 28 days. Morris water maze(MWM)task was conducted for evaluating learning and memory of the mice. ELISA was used to examine the levels of plasma corticosteroid. Results ATS dramatically ameliorated cognitive impairments and decreased serum corticosteroid level in the stressed mice(P<0.01). Conclusion ATS improves cognitive deficits provoked by chronic stress in mice ,which may attribute to decreasing plasma corticosteroid levels.
