Role of ultrasonography and Ki-67 expression in evaluation of neoadjuvant chemotherapy for breast can- cer
10.3969/j.issn.1006-5725.2017.16.017
- VernacularTitle:彩色多普勒超声及Ki-67表达对乳腺癌新辅助化疗疗效评价的应用价值
- Author:
Lishan CAI
;
Ling CHEN
;
Jianxing ZHANG
;
Qiuye YANG
- Keywords:
breast cancer;
neoadjuvant chemotherapy;
ultrasonography;
Ki-67 expression
- From:
The Journal of Practical Medicine
2017;33(16):2674-2677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of ultrasonography and Ki-67 before and after neoadjuvant chemotherapy for breast cancer ,and to assess the value of ultrasonography and Ki-67 in the evaluation of neoadju-vant chemotherapy for breast cancer. Methods The focus changes of 122 cases of breast cancer before and after neoadjuvant chemotherapy were observed by Color Doppler ultrasonography. The therapeutic effect was evaluated by RECIST standard,and the changes of Ki-67 before and after chemotherapy were observed. Results There were significant differences in size and internal blood flow signal of breast cancer before and after chemotherapy (P <0.05). The sensitivity of ultrasonography in the evaluation of neoadjuvant chemotherapy for breast cancer was 89.3%and specificity 53.8%. The clinical efficiency of neoadjuvant chemotherapy for breast cancer with high Ki-67 expression was higher than that with low Ki-67 expression. Conclusion Ultrasonography shows high clinical value in the evaluation of neoadjuvant chemotherapy for breast cancer ,and the expression of Ki-67 could predict the effi-cacy of neoadjuvant chemotherapy.
