Effects of a-keto acid combined with low protein diet on oxidative stress and electrolyte level in diabetic nephropathy
10.3969/j.issn.1006-5725.2017.16.028
- VernacularTitle:α-酮酸联合低蛋白饮食治疗糖尿病肾病对机体氧化应激及电解质水平的影响
- Author:
Jinsong LIANG
;
Wenlin SONG
;
Yan WU
- Keywords:
diabetic nephropathy;
α-keto acid;
low protein diet
- From:
The Journal of Practical Medicine
2017;33(16):2717-2720
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of α-keto acid combined with low protein diet on oxidative stress and electrolyte levels in patients with diabetic nephropathy. Methods Ninety-eight cases with type 2 diabetic nephropathy were randomLy divided into the treatment group(low-protein diet with α-keto acid 1 tablet,n=58) and the control group(normal protein intake,n=40). The 24 h urinary albumin excretion rate,glomerular filtra-tion rate ,serum oxidative stress (SOD ,MDA ,AOPPs) and electrolyte levels were measured before and after treatment. Results After 24 weeks of treatment,the 24 h urinary albumin excretion rate of DN patients in the treatment group was significantly lower than that before treatment and the control group (P < 0.05). However, there was no significant change in the glomerular filtration rate of the patients. Compared with the control group , the serum SOD activity of DN patients was significantly increased and the levels of MDA and AOPPs were decreased(P < 0.05)after 24 weeks of treatment. Simultaneously,the levels of serum potassium and phosphorus in the treatment group was decreased ,while the levels of calcium and magnesium were improved (P < 0.05). Conclusion α-keto acid combined with low protein diet can significantly reduce the urinary albumin excretion rate,improve the body′s antioxidant activity,and maintain serum electrolytes balance.
