Correlation between ApoE gene polymorphism and cardio-cerebrovascular diseases
10.3969/j.issn.1006-5725.2017.16.043
- VernacularTitle:载脂蛋白E基因多态性与心脑血管疾病的相关性
- Author:
Changlin ZHU
;
Weixuan LI
;
Meizhu LI
- Keywords:
apolipoprotein E(ApoE);
cardio-cerebrovascular diseases;
gene polymorphism;
serum lipid
- From:
The Journal of Practical Medicine
2017;33(16):2773-2776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between apolipoprotein E gene polymorphism and car-dio-cerebrovascular diseases. Methods Gene chip method was used to determine ApoE genotypes in 1427 pa-tients with cardiovascular disease and 450 health controls. Levels of serum lipid were compared. Results The highest genotype frequency of ApoE was ε3/3 in the patient group and control group. The allele frequency of ApoE from high to low wasε3,ε2 andε4. The genotype ofε3/3 in patient group was significantly lower than that in con-trol group(χ2 = 12.562,P < 0.01),whileε3/4 was significantly higher than that in control group(χ2 = 36.112, P < 0.01). No significant differences were found between patient groups in genotype or allele frequency of ApoE. The level of TCH,TG,LDL-c and sdLDL in the patient group were significantly higher than those in the control group,and HDL-c was significantly lower than those in the control group(P>0.05). The level of TCH and LDL-c significantly decreased in patients with E2 genotype,and increased in patients with genotype E4(P < 0.05). No significant differences were found in other indexes(P>0.05). Positive relationship was found between ApoE geno-type and phenotype of ApoE and LDL-c. Conclusions ApoE gene polymorphism plays an important role in the oc-currence and development of cardio-cerebrovascular diseases.
