Effect of controlled low threshold blood pressure on the expression of A β42 and p-Tau-181 protein in cerebrospinal fluid and cognition after operation in aged rats
10.3969/j.issn.1006-5725.2017.15.013
- VernacularTitle:控制性阈值低血压对老年大鼠Tau和Aβ表达及术后认知影响
- Author:
Ying CHEN
;
Fuzhou HUA
;
Zhidong ZHOU
;
Lieliang ZHANG
;
Jing ZHANG
;
Gen WEI
;
Yingping LIANG
;
Guohai XU
- Keywords:
hypotension;
cerebrospinal fluid;
Aβ-42;
p-Tau-181 protein;
cognition
- From:
The Journal of Practical Medicine
2017;33(15):2478-2481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different duration hypotension thresholds on p-Tau-181 and Aβ-42 protein expression and cognition in rats. Methods Thirty-nine healthy male SD rats were randomly di-vided into 4 groups:the control group(group C,n=9),the hypotension group(groupA1、A2、A3 ,n=10). The blood pressure of groupA1、A2、A3 was measured in different time of 2 h、4 h、6 h ,for 5 days. The antihyperten-sive group of mean arterial pressure(MAP)were maintained in the 50~55 mmHg safe range. Morris water maze was used to detect the spatial learning and memory ability of rats. The levels of Aβ42 and p-Tau-181 were detected by ELISA. Results There was no significant difference in mortality of rats in each group (P > 0.05). Compared with the group C,the escape latency and swimming distance of A2 group and A3 group were increased(P<0.05). In 3~7 days after operation,the cerebrospinal fluid P-Tau-181 and Aβ42 protein expression increased in the A2 group and A3 group compared with the A1 group(P<0.05). The escape latency and swimming distance of the A2 group and the A3 group were significantly longer than those in the control group. Aβ42 and p-Tau-181 were signifi-cantly increased in A3 group(P < 0.05). Compared with the A2 group,the increase of Aβ42 and p-Tau-181 in the A3 group was not significant(P<0.05). Conclusion Long-term controlled hypotension may lead to postoper-ative cognitive dysfunction which may relate to the increase of Aβ42 and p-Tau-181 protein expression.
