The features and correlation analysis of clinico-pathological and expression of PLA2R in idiopathic mem-branous nephropathy
10.3969/j.issn.1006-5725.2017.15.025
- VernacularTitle:特发性膜性肾病临床、病理特点及M型磷脂酶A2受体表达的相关分析
- Author:
Xiaobin LIU
;
Qiuhua ZHANG
;
Yong CHEN
;
Shaojun LIU
;
Bin LIU
;
Zhijian ZHANG
;
Yue ZHANG
;
Zhigang HU
;
Biao HUANG
;
Zhuxing SUN
;
Liang WANG
- Keywords:
Idiopathic membranous nephropathy;
nephrotic syndrome;
renal biopsy;
phospholipase A2 receptor
- From:
The Journal of Practical Medicine
2017;33(15):2520-2524
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the features and correlation analysis of clinico-pathological and expression of phospholipase A2 receptor(PLA2R)in idiopathic membranous nephropathy. Methods A number of 244 patients of IMN proved by renal biopsy were recruited in Wuxi People's Hospital from July 2008 to February 2015. Data were restrospectively collected. Results In the 244 IMN patients(mean age 54.07 ± 15.22 years,130 males and 114 females),44.3% had hypertension and 62.7% had nephrotic syndrome. Compared with female patients ,male patients had more severe proteinuria and lower eGFR(P < 0.05). Compared with the group of proteinuria < 4 g/24 h,the groups of proteinuria 4~8 g/24 h and > 8 g/24 h had higher level of cholesterol and blood pressure ,lower eGFR and more severe tubulointerstitial lesions(P < 0.05). Pathological stage Ⅰ and Ⅱaccounted for 98%,and there were more severe tubulointerstitial lesions and lower eGFR in the patients of stage Ⅱthan that in the patients of stageⅠandⅠ~Ⅱ(P<0.05). The positive rate of PLA2R accounted for 84.3%. Lower eGFR and more severe tubulointerstitial lesions were found in PLA2R-positive patients than those in PLA2R-neg-ative patients(P < 0.05). Multiple regression analysis showed that tubulointerstitial lesions(B =-7.253),hyper-tension ratio(B=-10.726)and the level of cholesterol(B=-2.077)had negative correlations with eGFR(P<0.01, R2=0.470). Conclusions IMN patients of male gender,grave proteinuria,high pathological stage and positive PLA2R should be treated more actively , since severe tubulointerstitial lesions and kidney injury were more common in those patients.
