The correlation of serum SOD and CD4+CD25+regulatory T cell in the mechanism of severe sepsis

VernacularTitle:严重脓毒症发病中血清超氧化物歧化酶与CD4+CD25+Treg细胞的相关性
Author: Junling LI ; Hancong WU ; Tao DENG ; Yixian LIANG ; Chunming LIN ; Wenlong DENG ; Jie ZHANG ; Manni QIN
Keywords: severe sepsis; superoxide dismutase; CD4+CD25+regulatory T cell
From: The Journal of Practical Medicine 2017;33(15):2536-2538
CountryChina
Language:Chinese
Abstract: Objective To evaluate the condition of oxidative stress and immunosuppression in early stage of severe sepsis,and investigate the correlation between them. Methods A prospective random control study in-cluded patients group(n=51)and control group(n=31). The concentration of serum superoxide dismutase was measured by enzyme linked immunosorbent assay(ELISA),CD4+CD25+Treg% was measured by flow cytometry , respectively. The difference between two groups was compared and the correlation between parameters in patients group was evaluated. Results The concentration of serum SOD was lower than control group (P < 0.01). CD4+CD25+Treg% significantly high,compared to the control group(P < 0.01). There was no strong correlation be-tween parameters in patients group. Conclusion Oxidative stress and immunosuppression are exist in the early stage of severe sepsis.