Preventive effect of trimetazidine on contrast - induced nephropathy in patients with chronic renal insufficiency after coronary intervention
10.3969/j.issn.1006-5725.2017.15.035
- VernacularTitle:曲美他嗪对肾功能不全患者冠脉介入术后造影剂肾病的预防作用
- Author:
Zeyuan FAN
;
Hanhua JI
- Keywords:
contrast-induced nephropathy;
trimetazidine;
renal dysfunction;
renoprotection
- From:
The Journal of Practical Medicine
2017;33(15):2558-2562
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was to investigate the role of trimetazidine in the prevention of contrast-induced nephropathy (CIN) in renal dysfunction patients undergoing coronary angiography. Methods A total of 151 patients with renal dysfunction who underwent coronary angiography were enrolled in our study and randomly divided into control group (n=77) and trimetazidine group (n=74). Standard hydration was administered in all the patients. In trimetazidine group, patients were administered trimetazidine orally for 48 hours before and 7 days after coronary angiography. Adverse events were observed in 12 months. Results (1) For 24 h and 48 h after the procedure:levels of SCr and CysC in the control group were significantly increased compared with baseline levels; levels of SCr and CysC in trimetazidine group were not increased, compared with baseline levels;levels of SCr and CysC were lower in trimetazidine group than the control group. (2)The incidence of CIN was reduced in trimetazidine group compared with control group (22.1%vs 9.5%,P=0.034). (3) Kaplan-Meier analysis showed that the incidence of adverse events in trimetazidine group was lower compared with the control group (P = 0.003). Conclusions Trimetazidine in combination with standard hydration is more effective than isotonic saline alone in protecting renal function in patients with renal dysfunction who undergo coronary angiography.
