Prognostic significance ofneutrophil-to-lymphocyte ratioin ovarian cancer:A systematic review and meta-analysis of observational studies

VernacularTitle:中性粒细胞淋巴细胞比率对于预测卵巢癌患者预后的Meta分析
Author: Nan LIU ; Wanjun LUO ; Minzhen LU ; Ruoting XU ; Biwei XIE ; Yilin YANG ; Guobing LIU ; Qitao HUANG
Keywords: ovarian cancer; inflammatory; neutrophil; lymphocyte; prognosis
From: The Journal of Practical Medicine 2017;33(15):2589-2592
CountryChina
Language:Chinese
Abstract: Objective To obtain a more accurate assessment of prognostic significance of NLR in ovarian cancer. Methods A systematic literature search was conducted using the electronic databases PubMed ,Web of Science,and Embase up to May 2016. Hazard ratio(HR)and odds ratio(OR)with 95% confidence interval (95%CI)were calculated. Statistical analysis was performed using Stata 12.0. Results 12 studies,consisting of 3 ,854 patients ,were selected in this meta-analysis. High NLR level was significantly associated with poorer overall survival(OS)(HR:1.69)and shorter progression free survival(PFS)(HR 1.63). Additionally,increased NLR was significantly correlated with advanced FIGO stage(OR 2.32),higher level of CA-125(OR 3.33),more extensive ascites(OR 3.54)as well as less chemotheraputic response(OR 0.53). Conclusions Elevated pretreat-ment NLR can serve as a predicative factor of poor prognosis for ovarian cancer.