Genetics of Ossification of the Posterior Longitudinal Ligament of the Spine: A Mini Review.
10.11005/jbm.2014.21.2.127
- Author:
Shiro IKEGAWA
1
Author Information
1. Laboratory of Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan. sikegawa@ims.u-tokyo.ac.jp
- Publication Type:Review
- Keywords:
Genetic association studies;
Ossification of posterior longitudinal ligament;
Polymorphism
- MeSH:
Aging;
Genetic Association Studies;
Genetics*;
Longitudinal Ligaments*;
Ossification of Posterior Longitudinal Ligament;
Spinal Cord;
Spine*
- From:Journal of Bone Metabolism
2014;21(2):127-132
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease in aging populations and sometimes results in serious neurological problems due to compression of the spinal cord and nerve roots. OPLL is a multi-factorial (polygenic) disease controlled by genetic and environmental factors. Studies searching for the genetic component of OPLL, using linkage and association analyses, are in progress and several susceptibility genes have been reported. This paper reviews the recent progress in the genetic study of OPLL and comments on its future task.
