Investigation of the sedative effect of dexmedetomidine compound midazolam under different formula
10.3969/j.issn.1006-5725.2017.16.036
- VernacularTitle:不同配方右美托咪啶复合咪达唑仑的镇静效应
- Author:
Junli SI
;
Yongyong SHI
;
Weixian ZHAO
;
Jianbin XIAO
;
Jinhe DENG
- Keywords:
dexmedetomidine;
midazolam;
spinal anesthesia;
sedative effects
- From:
The Journal of Practical Medicine
2017;33(16):2747-2749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the sedative effects of different doses of dexmedetomidine with mid-azolam in spinal anesthesia. Methods 130 cases of spinal anesthesia were randomly divided into 2 groups,group D1 and group D2,with 65 cases in each group. Patients in 2 groups were given midazolam and dexmedetomidine with different doses. The heart rates ,blood pressure ,SpO2 ,Narcotrend value and Ramsay sedation scores were recorded at mutiple time points. The working time ,maintaining time of sedative effect ,and adverse reactions were compared between 2 groups. Results MAP,HR and NT decreased significantly in 2 groups(P < 0.05,respec-tively). The keeping time was relatively longer in group D1 compared with group D2(P<0.05). The working time was faster in group D2 compared with group D1. The rate of bradycardia in group D2 was relatively higher than that in group D1. Conclusion Good sedative effect can be obtained by drug in 2 groups. Group D1,with midazolam 0.05 mg/kg+dexmedetomidine 0.3μg/kg,may have a certain advantage in anaesthesia in the spinal canal.
