The effect of folic acid on plasma homocysteine and atherosclerosis in patients with type H hypertension
10.3969/j.issn.1006-5725.2017.16.038
- VernacularTitle:叶酸干预H型高血压患者血浆同型半胱氨酸及动脉硬化的疗效
- Author:
Xia GAO
;
Wei XIE
;
Xuefeng GUO
;
Xiang GAO
;
Shuo ZHANG
;
Zhanuer GU
;
Guyue XIE
;
Keyu JIN
;
Yifan YANG
;
Shifei SONG
- Keywords:
h-type hypertension;
folic acid;
homocysteine;
arteriosclerosis
- From:
The Journal of Practical Medicine
2017;33(16):2754-2756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of folic acid intervention on plasma homocysteine (Hcy) metabolic changes and pulse wave velocity(PWV)in patients with type H hypertension. Methods Patients(hos-pitalized from March 2014 to December in our hospital)with H type hypertension were randomly divided into treat-ment group and control group randomly ,and were given routine antihypertensive drug therapy. Treatment group was given oral folic acid 0.8 mg,1 times a day,the control group was given placebo,1 times a day. All patient were treated for 12 months. Changes of plasma Hcy and PWV levels were observed. Results 432 patients(Han nationality)with type H hypertension were enrolled in this study with the age of 61.7 ± 13.6 years old and the ratio of men and women is 1.3:1. The most common diseases were coronary heart disease and type 2 diabetes mellitus. 2 groups were treated for a period of 12 months,with follow-up time from 6 to 10 months(average duration in 8 months). After treatment,the difference between plasma Hcy(Z=-7.63,P=0.000)and PWV(Z=-3.16,P=0.002)levels of the two groups were statistically significant. Conclusion Folic acid intervention can significantly reduce the level of plasma Hcy in patients with type H hypertension ,slow down the progression of atherosclerosis and reduce the risk factors of cardiovascular disease.
