The latest progress of p-tau conformations in traumatic brain injury and relevant neurodegeneration

VernacularTitle:P-tau蛋白在颅脑损伤及相关神经退行性病中的研究进展
Author: Ruili LI
Keywords: Tau protein; Traumatic brain injury; Phosphorylated; Neurofi-brillary tangles
From: Journal of Medical Postgraduates 2017;30(8):889-892
CountryChina
Language:Chinese
Abstract: One of the common hallmark lesions of Alzheimer's disease (AD) brains is neurofibrillary tangles(NFTs), which are composed of phosphorylated tau protein (p-tau).NFTs are also a defining feature of other neurodegenerative disorders and have recently been identified in the patients suffering from chronic traumatic encephalopathy (CTE).Tau protein pathological change is the etiological factor of AD and CTE after traumatic brain injury (TBI), and CIS p-tau is an early driving factor of neurodegeneration after brain injury.CIS p-tau can induce tau protein pathology, and the detection of CIS p-tau in human may provide new diagnostic methods and prognostic measures.Furthermore, the individualized cis p-tau antibody could ultimately be developed as a new treatment for AD, TBI and CTE.This article reviews the mechanism of tau protein in TBI and neurodegeneration, the formation of CIS P-tau protein, the role of cistauosis and the progress of CIS p-tau antibody therapy.