The detecting value of CTCs in peripheral venous blood of patients with advanced metastatic breast cancer
10.3969/j.issn.1006-5725.2017.16.041
- VernacularTitle:外周静脉血循环肿瘤细胞在Ⅳ期乳腺癌寡转移与广泛转移中检测的临床价值
- Author:
Yan LI
;
Sunyu TAO
;
Caixia CUI
;
Xiaojing WANG
;
Shengping MIN
;
Duojie LI
- Keywords:
metastatic breast cancer;
circulating tumor cells;
oligometastases
- From:
The Journal of Practical Medicine
2017;33(16):2764-2768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the value of circulating tumor cells(CTCs)in peripheral venous blood in patients with metastatic breast cancer. Methods 50 female patients with advanced advanced metastatic breast can-cer hospitalized in our hospital from May 2016 to December 2016 were enrolled in the research. Patients were divid-ed into oligometastases group and extensive metastasis group through multi-department comprehensive analysis andimaging diagnosis. 10 cases with early stage breast cancer were selected randomly. 10 healthy female volunteers were recruited as control group. After obtaining written informed consent from research subjects ,7.5 mL peripheral blood was drew from patients and volunteers prior to starting a new line of chemotherapy ,surgery or other treat-ment. CTCs counts from Blood samples were detected density gradient centrifugation associate with flow cytometry. Results The base line was formulated as CTCs≥5/7.5 mL positive and CTCs<5/7.5 mL negative. By comparing the positive expression of CTCs in early and advanced metastatic breast cancer(Pa = 0.01,P < 0.05),positive CTCs was associated with advanced metastatic breast cancer. Comparision of the positive expression of CTCs between oligometastases group and the extensive transfer group showed significant difference in the CTCs count be-tween the two groups(Pb = 0.018,P < 0.05). In the corresponding period,no positive CTCs was detected in all healthy volunteers. Conclusion CTCs count was associated with metastatic breast cancer. There was a correlation between tumor metastasis and CTCs count (the more widely metastasis ,the higher the detection rate of CTCs). CTCs may be of relevant value in the diagnosis and treatment ,and prognosis evaluation of metastatic breast cancer.
