Research progress in the competing endogenous RNA in gastric cancer pathogenesis
10.3760/cma.j.issn.1009-9158.2017.08.017
- VernacularTitle:竞争性内源性RNA与胃癌发病机制研究进展
- Author:
Wenwen LIU
;
Feng WANG
;
Yan ZHANG
;
Shaoqing JU
- Keywords:
MicroRNAs;
RNA,long noncoding;
Pseudogenes
- From:
Chinese Journal of Laboratory Medicine
2017;40(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies demonstrate that the long non-coding RNAs (lncRNAs), pseudogenes, circular RNAs (circRNAs) and so on can be used as competitive endogenous RNAs (ceRNAs), binding to microRNAs (miRNAs), to regulate the expression level of their targets.This novel interplay optimizes traditional liner miRNA→RNA pattern and has become a research hotspot in the scientific community.Dysregulation of ceRNA interplay will influence the body′s normal life activities, leading to the occurrence of diseases, and even tumor formation.This article briefly introduces the key components of ceRNA crosstalk and its research progress in gastric cancer pathogenesis, so as to provide a new thought for cancer research, clinical diagnosis and therapeutics.
