Correlation of serum acute amyloid A level and activity of Behcet's disease

VernacularTitle:血清急性淀粉样蛋白A水平与白塞病活动度的相关性研究
Author: Zhenyuan ZHOU ; Yanwei LIN ; Nan SHEN ; Yu LU
Keywords: serum amyloid A; Behcet's disease; IL-8; biomarker
From: Journal of Shanghai Jiaotong University(Medical Science) 2017;37(7):955-958
CountryChina
Language:Chinese
Abstract: Objective·To investigate correlation of serum acute amyloid A (A-SAA) level and activity of Behcet's disease (BD).Methods·Blood samples from patients with active BD (n=40),remission BD (n=15),Takayasu disease (TA,n=12),rheumatoid arthritis (RA,n=25),systemic lupus erythematosus (SLE,n=25) and healthy donor (HD,n=25) were collected.Serum A-SAA,ESR,and CRP levels were detected and compared among groups.The correlation between A-SAA and its downstream IL-8 or International Society for Behcet's disease (ISBD) disease activity scores was analyzed as well.Results·Serum A-SAA level was significantly increased in the patients with active BD [(115.70±87.78) mg/L],as well as patients with RA and TA,which levels were (68.72±61.50) mg/L and (96.25±87.41) mg/L respectively,but remained unchanged in SLE patients.Moreover,serum A-SAA level was found correlated with ISBD score as well as IL-8 level.Conclusion·A-SAA can work as a detection index for evaluating BD activity.