Pre-clinical & clinical trials of Arterakin (dihydroartemisinin-piperaquine) in treatment of uncomplicated malaria in Vietnam
- Author:
Doan Hanh Nhan
- Publication Type:Journal Article
- Keywords:
Arterakin;
Malaria;
Treatment;
Dihydroartemisine;
Piperaquine;
- MeSH:
Malaria;
Therapeutics;
Artemisinins
- From:Journal of Malaria and parasite diseases Control
2004;0(3):36-43
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
A high therapeutic efficacy was found in the experimental mouse model infected with P. berghei (both chloroquin sensitive and resistant strains). At a low dose, as twice as the human dose and calculated as mg/kg of body weight of mice, the combination produced a high effect, clearing parasite within 3 days. However a considerable rate of recrudescence (10%) was found within 28 following-up days. At a high dose as tenth as a human dose, the combination was found to have a high therapeutic effect of 100% cure rate on mice clearing parasite within 2 days and no recurrence occured within 28 following-up days in all the tests. Arterakin was found to be a highly effective antimalaria drug with cure rate of 100% and a fast parasite clearance time (1-2 days) in both P falciparum and P. vivax infected patients. The total dose of 8 tablets for 3 days for adults and relevant doses for children appeared to be appropriate
