Association study on interaction effects of 5-HT receptor related genes and suicidal behavior in major depressive disorder
10.3760/cma.j.issn.1674-6554.2017.07.007
- VernacularTitle:5-羟色胺受体相关基因的交互作用与抑郁症自杀行为的关联研究
- Author:
Zhuowen LI
;
Jingsong MA
;
Dong QI
;
Jian ZHANG
;
Xiaohui QIU
;
Xiuxian YANG
;
Zhengxue QIAO
;
Lin WANG
;
Yanjie YANG
- Keywords:
Depression;
5-TH receptor;
Single nucleotide polymorphism;
Gene interaction;
Haplotype;
Linkage disequilibrium
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2017;26(7):610-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the single nucleotide polymorphisms(SNPs) of 5-HT1BR(rs6298),5-HT2AR(rs6311,rs6313) and 5-HT2BR(rs765458) gene,and their gene-gene interactions on suicidal behavior in major depressive disorder.Methods The blood samples were taken from 281 depression patients with impulsive suicide attempt and 281 age-matched healthy controls from a hospital in Harbin city,Heilongjiang province.The DNA isolated from blood samples and was genotyped using TapMan SNP genotyping probe.χ2 test was used to compare differences in the distribution of gene alleles between cases and controls.Haplotype and linkage disequilibrium(LD) analysis was performed using Haploview 4.0 software.GMDR was used to analyze the gene-gene interaction.Results The rs6313 and rs6311 of the 5-HT2AR gene were in strong linkage disequilibrium (D=0.756,r2=0.375).There was a significant gene-gene interaction of 5-HT1BR (rs6298),5-HT2AR (rs6311,rs6313) and 5-HT2BR(rs765458) on suicidal behavior(P<0.05).In this model,the test accuracy was 0.6182 and CV value was 10/10.Conclusion A haplotype containing rs6311 and rs6313 of 5-HT2AR gene is associated with suicidal behavior.The interaction of 5-HT1BR gene (rs6298),5-HT2AR gene (rs6311,rs6313) and 5-HT2BR gene (rs765458) are associated with depression suicidal behavior.
