Cognitive deficits of the elderly with depression and 1 H-MRS changes in its frontal lobe and hippocampus
10.3760/cma.j.issn.0254-9026.2017.07.008
- VernacularTitle:老年期抑郁患者的认知功能及其磁共振质子波谱研究
- Author:
Huishi ZHANG
;
Min LIU
;
Xue YANG
;
Yongjie ZHOU
- Keywords:
Depression;
Cognition;
Magnetic resonance spectroscopy
- From:
Chinese Journal of Geriatrics
2017;36(7):746-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the features of cognitive deficits of elderly depression,to evaluate the metabolite changes using MRS,and to assess the correlation between abnormal metabolite ratio of MRS and the scores of MoCA.Methods The samples contained 20 elderly depression patients and 20 healthy controls.All the patients were assessed by Montreal Cognitive Assessment(MoCA).MRS data were acquired by point-resolved echo spin spectroscopy(PRESS)sequence of single vowel 1-hydrogen MRS.The software automatically completed metabolite content measurement,giving the ratio of all metabolite using Cr as reference,including NAA/Cr,Cho/Cr.Results (1)Compared with the controls,the patients depressed had lower scores in attention,executive function,words,delayed recall and total scores(P<0.01);(2)The patients depressed had lower ratio of NAA/Cr in both frontal lobe(P<0.05)and hippocampus(P<0.01),there were no significant differences in Cho/Cr between two groups(P>0.01);(3)The scores in executive function(r=0.71,0.62),words(r=0.79,0.77),delayed recall(r=0.62,0.61)and total scores(r=0.72,0.68)correlated with NAA/Cr in frontal lobe,the scores in delayed recall correlated with NAA/Cr in hippocampus(r=0.81,0.76).Conclusions The cognition function of patients with elderly depression can be generally impaired.The patients depressed had lower ratio of NAA/Cr in both frontal lobe and hippocampus.The cognitive deficits of geriatric depression correlated 1H-MRS changes in its frontal lobe and hippocampus.
