Virulence genes of Parkinson's disease and autophagy
10.3760/cma.j.issn.0254-9026.2017.07.029
- VernacularTitle:帕金森病的致病基因与自噬
- Author:
Dan ZHOU
;
Jiajun CHEN
;
Xiangwei MENG
;
Lei ZHANG
- Keywords:
Autophagy;
Lysosomes;
Parkinson disease
- From:
Chinese Journal of Geriatrics
2017;36(7):826-829
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a common neurodegenerative disease mainly affecting old persons.The pathogenesis of PD is still unclear, although it has been studied for many years.Recently, more and more evidences show that the dysfunction of autophagy plays a pivotal role in the pathogenesis of PD.Substantial progress in the genetic research of PD has showed that several pathogenic genes were identified correlated with autophagy, in particular, playing an important role in sporadic cases of PD.Here, we will discuss pathogenic genes-correlated dysfunctional autophagy-lysosomes system, so as to specify the pathogenesis of PD and provide a clue for its treatment.
