Preliminary study on manufacture process of transdermal patch of nitroglycerin
- Author:
Hoang Minh Chau
- Publication Type:Journal Article
- Keywords:
nitroglycerin, drug, manufacture, transdermal patch
- MeSH:
Nitroglycerin;
Chromatography, High Pressure Liquid;
Adjuvants, Pharmaceutic
- From:Pharmaceutical Journal
2003;321(1):15-18
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Nitroglycerin, a vasoactive substance, has been used in the treatment of vagina for more than 100 years. To sustain the pharmaceutical effect, doses were administered every 2 hours. Recently the transdermal delivery systems have became popular. Based on eudragit E 100, we combined it with plasticizer (dibutyl sebacate/triethyl citrate), crosslinker (succinic acid), active ingredient (nitroglycerin) and further excipients (e.g. permation enhances: ethyl alcohol) to form a self adhesive matrix system for use in nitroglycerin patch. The concentration of nitroglycerin in the patch was determined by HPLC assay
