Roles of occludin in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2017.06.010
- VernacularTitle:闭合蛋白在脑缺血中的作用
- Author:
Ke YANG
;
Ting WANG
;
Yuan ZHANG
- Keywords:
Stroke;
Brain Ischemia;
Occludin;
Blood-Brain Barrier;
Brain Edema;
Cerebral Hemorrhage
- From:
International Journal of Cerebrovascular Diseases
2017;25(6):541-545
- CountryChina
- Language:Chinese
-
Abstract:
Blood-brain barrier (BBB) injury is an important pathological change of ischemic stroke.Occludin constitutes the major component of the tight junction of BBB, which plays a significant role in maintaining the BBB integrity.Cerebral ischemia initiates occludin degradation through the induction of the activation of inflammatory mediators, reactive oxygen, and matrix metalloproteinases, and causes the changes of tight junction cytoskeletal protein interaction, resulting in BBB integrity destruction and increased permeability.This article mainly elaborates the relationships of occludin with BBB, brain edema and hemorrhagic transformation, as well as the possibility of occludin as an intervention target for ischemic stroke.
