Correlation between neutrophil to lymphocyte ratio and cerebral microbleeds in patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2017.06.006
- VernacularTitle:中性粒细胞/淋巴细胞比值与急性缺血性卒中患者脑微出血的相关性
- Author:
Yun ZHANG
;
Jian SHI
;
Shiquan WEN
;
Qian LUO
;
Zhonglun CHEN
;
Xianwen ZHANG
;
Hongcai DU
;
Shanshan ZHANG
;
Jinfeng DUAN
- Keywords:
Stroke;
Brain Ischemia;
Cerebral Hemorrhage;
Neutrophils;
Lymphocytes;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2017;25(6):521-525
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the correlation between neutrophil to lymphocyte ratio (NLR) and cerebral microbleeds (CMBs) in patients with acute ischemic stroke.MethodsThe consecutive inpatients with acute ischemic stroke were prospectively enrolled.Gradient echo-T2*-weighted imaging was used to evaluate CMBs and their quantity.Univariate analysis was used to compare the baseline data between the CMB group and the non-CMB group.Multivariable logistic regression analysis was used to identify the independent correlation between NLR and CMBs.ResultsA total of 218 patients with acute ischemic stroke were prospectively enrolled, including 66 (30.3%) with CMBs.The age (64.7±6.6 years vs.66.9±8.6 years;t=2.052, P=0.041), high sensitive C-reactive protein (7.0[2.3-13.9] mg/L vs.8.9[4.0-28.1] mg/L;Z=2.008, P=0.045) and NLR (1.9[1.4-2.9] vs.2.3[1.7-3.6];Z=2.071, P=0.038) in the non-CMB group were significantly lower than those of the CMB group.Multivariate logistic regression analysis showed that NLR (odds ratio 1.276, 95% confidence interval 1.008-1.670;P=0.045) and age (odds ratio 1.044, 95% confidence interval 1.002-1.087;P=0.040) were the independent risk factor for CMBs.Spearman correlation analysis showed that NLR was significantly positively correlated with the severity of CMBs (r=0.210, P=0.007).ConclusionsIn patients with acute ischemic stroke, NLR was associated with CMBs and their severity, suggesting that inflammatory reaction might be involved in the occurrence of CMBs.
