Amplitude of low frequency fluctuation in depressive patients with diurnal rhythm: a resting-state fMRI study
10.3760/cma.j.issn.1674-6554.2017.07.006
- VernacularTitle:晨重夕轻抑郁症患者静息态功能磁共振低频振幅研究
- Author:
Jiting GENG
;
Rui YAN
;
Zhaoqi MO
;
Yu CHEN
;
Jiabo SHI
;
Qing LU
;
Zhijian YAO
- Keywords:
Depression;
Diurnal rhythm;
Functional magnetic resonance;
Amplitude of low frequency fluctuations
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2017;26(7):605-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the energy feature of the spontaneous neural activity in depressive patients with diurnal rhythm.Methods Twenty depressive patients with diurnal rhythm,20 depressive patients without diurnal rhythm and 20 gender-,age-,education-matched healthy controls were scanned with 3.0 T MRI Scanner.According to Results of ANOVA,group-wise two sample t-test was completed.The correlation analysis were conducted between ALFF of significant difference brain regions and the score of Hamilton rating scale for depression.Results The brain regions showing significant differences among three groups were located in the right parahippocampal gyrus(MNI:18,-36,-9;K=136),left parietal lobe(MNI:-54,-45,42;K=86),left cerebellum crus(MNI:-84,-60,36;K=86) and right cerebellum crus(MNI:9,-78,-36;K=91)(P<0.05,Alphasim correct).Compared with non-diurnal rhythm group,the diurnal rhythm group showed significantly increased ALFF in the right parahippocampal gyrus.Compared with healthy group,the diurnal rhythm group showed significantly increased ALFF in right parahippocampal gyrus,left parietal lobe,and significantly decreased ALFF in left cerebellum crus 1 and right cerebellum crus 2.Compared with healthy group,the non-diurnal rhythm group showed significantly increased ALFF in left parietal lobe,and significantly decreased ALFF in left cerebellum crus 1 and bilateral cerebellum crus 2.No correlation between ALFF of significant difference brain regions and clinical symptoms was found(P>0.05).Conclusion The diurnal rhythm observed in depression may be associated with aberrant activity of parahippocampal gyrus.
