Neuroprotective effects of minocycline in ischemic stroke
10.3760/cma.j.issn.1673-4165.2017.06.012
- VernacularTitle:米诺环素对缺血性卒中的神经保护作用
- Author:
Zhenguang LI
;
Xinghua CUI
;
Jinbiao ZHANG
;
Pengfei WANG
;
Junwu ZHAO
- Keywords:
Stroke;
Brain Ischemia;
Minocycline;
Inflammation;
Oxidative Stress;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2017;25(6):550-554
- CountryChina
- Language:Chinese
-
Abstract:
Minocycline is the second generation semisynthetic tetracycline antibiotics.A variety of animal models and clinical trials have shown that it has neuroprotective effect.Its mechanism is associated with inhibiting apoptosis, alleviating inflammatory reaction, reducing infarct volume, and alleviating vascular injury.This article reviews the neuroprotective effect of minocycline in preclinical phase and early clinical trials of acute ischemic stroke.
