Clinical and molecular characteristics of invasive community-acquired methicillin-resistant Staphylococcus aureus infection in Chinese neonates
10.3760/cma.j.issn.0254-5101.2017.07.013
- VernacularTitle:新生儿侵袭性社区获得性耐甲氧西林金黄色葡萄球菌的临床及分子特点研究
- Author:
Wenjing GENG
;
Fang DONG
;
Jingwen WENG
;
Shixiao DONG
;
Fei JIN
;
Xuzhuang SHEN
;
Yujie QI
- Keywords:
CA-MRSA;
Neonate;
Invasive infection
- From:
Chinese Journal of Microbiology and Immunology
2017;37(7):552-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical and molecular features of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection in neonates and to investigate their antibiotic resistance profiles.Methods A total of 35 invasive CA-MRSA strains were collected from six hospitals in 2014.Multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) typing and spa typing were used to analyze these isolated CA-MRSA strains.In vitro antibiotic susceptibilities of those strains to 15 antibiotics were analyzed by using agar dilution method.Results Up to 88.6% patients were late-onset infection and septicemia (24, 68.5%) was the most common infection among the 35 cases.A total of 16 patients (45.7%) suffered from complications.Caesarean section and premature birth were risk factors for invasive CA-MRSA infection.ST59-MRSA-SCCmecⅣa-t437 (14, 40%) was the most predominant CA-MRSA clone, followed by ST59-MRSA-SCCmecⅤ-t437 (13, 37.1%).The incidence of severe complications caused by ST59-MRSA-SCCmecⅤ-t437 was higher than that caused by ST59-MRSA-SCCmecⅣa-t437 (P<0.05).Up to 85.7% of the isolated CA-MRSA strains were multidrug-resistant strains.Conclusion This study shows that neonatal invasive CA-MRSA infections mainly result in septicemia and are often accompanied by complications and involve multiple organs.Multidrug-resistant CA-MRSA strains are prevalent in neonates.ST59-MRSA-SCCmecⅣa-t437 is the predominant clone causing neonatal invasive CA-MRSA infection.