The application and research progress of plasma heparin-binding protein in septic shock
10.3760/cma.j.issn.1009-9158.2017.07.016
- VernacularTitle:血浆肝素结合蛋白在脓毒性休克中的研究及应用进展
- Author:
Wei REN
;
Miao WU
;
Jie WEI
;
Yan LI
- Keywords:
Shock;
septic;
Blood proteins;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2017;40(7):548-551
- CountryChina
- Language:Chinese
-
Abstract:
Septic shock is the most serious stage of sepsis and the main cause of the high mortality.So far,the scientists have paid more attentions on biomarkers for the early diagnosis and therapy monitoring of septic shock.As a kind of acute phase proteins, heparin-binding protein (HBP)has functions with increasing vascular permeability, sterilization, chemotaxis and regulating cell apoptosis.When the level of plasma HBP is high, it suggests that the patient has severe sepsis with edema and vascular collapse and can beapplied as a valuable biomarker for early diagnosis and therapy monitoring of septic shock.This review focuses on common inflammatory biomarkers for clinical application of sepsis, as well the structure and function of HBP and its clinical application of septic shock.
