Formula and Preparation of Cantharidin Chitosan Bioadhesive Microspheres by Spray Drying
- VernacularTitle:喷雾干燥法制备斑蝥素壳聚糖生物黏附微球的处方工艺研究
- Author:
Lin Lü
;
Xiaoming HE
;
Deying CAO
;
Qing DU
;
Yunjie DANG
- Keywords:
Cantharidin;
Chitosan microspheres;
Bioadhesive;
Response surface methodology
- From:
China Pharmacist
2017;20(8):1344-1348
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the formula and preparation technology of cantharidin chitosan bioadhesive microspheres.Methods: The microspheres were prepared by a spray drying method.A single-factor experiment was used to study the effect of chitosan with different molecular weight on the gastric mucosa adhesion rate were also studied, and the effects of different drug loading ratio, concentration of chitosan acetic acid solution and speed of peristaltic pump on the loading rate were also studied.The cantharidin entrapment efficiency as the studying index, a response surface method was used to further optimize the formula.Results: The best formula and preparation process of cantharidin chitosan bioadhesive microspheres were as follows: the concentration ratio of antharidin to chitosan was 19.83% , the concentration of chitosan acetic acid solution was 0.77% , and the peristaltic pump flow rate was 9.225 ml·min-1.With the best formula, the entrapment efficiency of cantharidin chitosan bioadhesive microspheres was 90.14%.Conclusion: The microsphere preparation by the spray drying method is stable and repeatable.Cantharidin chitosan bioadhesive microspheres have high entrapment efficiency and promising biological adhesion.
