Determination of Chloride Ion and Sulfate Ion in Ethylparaben by Ion Chromatography and Quality Evaluation of Products at Different Levels
- VernacularTitle:离子色谱法测定羟苯乙酯中氯离子和硫酸根离子及不同级别产品质量状况的评价
- Author:
Gui SU
;
Yanming LIU
;
Haiyan LONG
;
Ying LI
;
Fan ZHANG
;
Pujun ZENG
- Keywords:
Ion chromatography;
Ethylparaben;
Chloride ion;
Sulfate ion;
Quality control
- From:
China Pharmacist
2017;20(8):1367-1370
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish an ion chromatography (IC) method to determine the content of chloride ion and sulfate ion in ethylparaben, and evaluate the quality status of chloride ion and sulfate ion in ethylparaben at different levels.Methods: Ion chromatograph was used.The column was Dionex IonPac AS 18 (250 mm ×4 mm,5 μm) using potassium hydroxide as the mobile phase with gradient elution, the flow rate was 1.0 ml·min-1 , the injection volume was 25 μl, and the quantitative method was standard curve.Results: The method showed good linear relationship within the range of 0.02-4.00 μg·ml-1 for chloride ion (r=0.999 9) and 0.10-10.00μg·ml-1 for sulfate ion (r=0.999 5).The average recovery was 90.12% (RSD=3.4%) and 85.54% (RSD=6.2%) for chloride ion and sulfate ion, respectively (n =9).The content range of chloride ion and sulfate ion was 0.000 3%-0.015 7% and 0.000 9%-0.024 4% in 63 batches of samples, respectively.Conclusion: The established method is simple, fast and accurate, which can be used to determine the contents of chloride ion and sulfate ion in ethylparaben and is helpful to its quality control.
